李寧求，男，博士，研究員，博士生導師，中國水產科學研究院水產疫苗創制與免疫防控創新團隊首席，農業農村部漁用藥物創制重點實驗室副主任。長期從事鱖鱸鱧等特色魚類疫苗創制與免疫防控、疫病區域化控制、無病毒苗種繁育與抗病毒新品種選育等，先后主持和參與了國家自然科學基金、國家重點研發計劃、國家863計劃、國家科技支撐計劃（攻關計劃）、公益性農業行業專項等重大項目20余項。獲各類成果獎勵6項、共發表學術論文180余篇（第1作者或通訊作者論文80余篇）、獲授權國家發明專利26、參編著作5部。入選中國水產科學研究院“領軍人才計劃”和“中青年科技拔尖人才”等。
聯系方式：
（1）電話：13533755943
（2）郵箱：liningq@126.com
研究方向：
1.病原致病與宿主免疫機制
2.漁用疫苗創制與免疫防控
3.疫病區域化控制技術
4.無病毒苗種繁育與抗病毒新品種選育
主持的重點項目（僅限5項）
1.國家自然科學基金面上項目：ISKNV ORF62L調控IDH重構宿主谷氨酰胺還原性代謝機制研究，項目主持，2023-2026。
2.國家自然科學基金面上項目：ISKNV通過PI3K-Akt-mTOR通路調控鱖腦細胞自噬機制研究，項目主持，2019-2022。
3.國家重點研發計劃項目：淡水養殖魚類重大疫病區域化免疫防控技術及示范，子課題主持，2019-2022.
4.國家重點研發計劃項目：水產動物重要病原及其生物學特征與毒力基礎，子課題主持，2018-2022.
5.廣東省級促進經濟高質量發展專項資金：海洋源虹彩病毒高效疫苗創制與應用，項目主持，2022-2024.
代表論文與著作（限第1作者及通訊作者）
1.Fangying Li, Xiaozhe Fu, Xia Luo, Qiang Lin, Hongru Liang,Yinjie Niu, Lihui Liu，Ningqiu Li. Role of asparagine biosynthesis pathway in Siniperca chuatsi rhabdovirus proliferation. Frontiers in Microbiology 2023，14:1165491
2.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Xia Luo, Shaozhi Zuo, Lihui Liu and Ningqiu Li*. Epidermal growth factor receptor promotes infectiousspleen and kidney necrosis virus invasion via PI3K-Akt signaling pathway. Journal of General Virology 2023;104:001882
3.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Xia Luo, Shaozhi Zuo, Lihui Liu, Ningqiu Li*. In vivo and in vitro, antiviral effects of two mixture of Chinese herbal drug active monomers against MSRV and LMBV in largemouth bass (Micropterus salmoides). Aquaculture 577 (2023) 739977
4.Xiaozhe Fu, Mingju Luo, Guo Zheng，Hongru Liang, Lihui Liu, Qiang Lin, Yinjie Niu, Xia Luo, Ningqiu Li*. Determination and Characterization of a Novel Birnavirus Associated with Massive Mortality in Largemouth Bass. Microbiology Spectrum 2022, 10(2): e01716-21
5.Xiaozhe Fu, Kejin Li, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Lihui Liu, Ningqiu Li*.The mTOR SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells. Microbiology Spectrum 2022, 10(1): e02310-21
6.Hongru Liang, Xiaozhe Fu, Qiang Lin, Lihui Liu, Zhibin Huang, Yinjie Niu, Luo Xia, Ningqiu Li*.Inhibition of grass carp reovirus with PEGylated aptamers. Aquaculture 559 (2022) 738412
7.Xiaoting Zhang , Yue Ming1, Xiaozhe Fu , Yinjie Niu , Qiang Lin , Hongru Liang , Xia Luo , Lihui Liu , Ningqiu Li*. PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responses. Fish and Shellfish Immunology 120 (2022) 648–657
8.Yinjie Niu , Xiaozhe Fu , Qiang Lin , Hongru Liang , Xia Luo , Shaozhi Zuo , Lihui Liu , Ningqiu Li*. The composition and antiviral activity of scTRIM59 in Mandarin fish. Fish and Shellfish Immunology 130 (2022) 86–92
9.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Lihui Liu, Xia Luo, Hongru Liang, Ningqiu Li*. Gefitinib inhibits infectious spleen and kidney necrosis virus infection in vivo and vitro by blocking virus endocytosis. Aquaculture 539 (2021) 736614
10.Hongru Liang, Lixi Zhang, Xiaozhe Fu, Qiang Lin, Lihui Liu, Yinjie Niu, Xia Luo, Zhibin Huang and Ningqiu Li*. Development of a double-Antibody Sandwich ELISA for Rapid Detection of the MCP Antigen Concentration in Inactivated ISKNV Vaccines. Vaccines 2021, 9, 1264
11.Xia Luo, Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Lihui Liu and Ningqiu Li*. Large-Scale Microcarrier Culture of Chinese Perch Brain Cell for Viral Vaccine Production in a Stirred Bioreactor. Vaccines 2021, 9, 1003
12.Xiaozhe Fu, Yue Ming, Chen Li, Yinjie Niu, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Ningqiu Li*. Siniperca chuatsi rhabdovirus (SCRV) induces autophagy via PI3K/AktmTOR pathway in CPB cells. Fish and Shellfish Immunology 102 (2020) 381–388.
13.Xiaozhe Fu, Lixi Zhang, Lihui Liu, Qiang Lin, Hongru Liang, Yinjie Niu, Zhibin Huang, Ningqiu Li*. Identification of intron in ORF003 gene and its application for inactivation test of ISKNV. Microbial Pathogenesis 138 (2020) 103822
14.Yinjie Niu, Xiaozhe Fu, Lihui Liu, Qiang Lin, Hongru Liang, Zhibin Huang, Ningqiu Li*. Molecular characterization and function of EGFR during viral infection process in Mandarin fishSiniperca chuatsi. Fish and Shellfish Immunology 102 (2020) 211–217
15.Xixi Guo, Yang Zhou, Xiaozhe Fu, Qiang Lin, Lihui Liu, Hongru Liang, Yinjie Niu, Ningqiu Li*. Transcriptomic profiles reveal that inactivated iridovirus and rhabdovirusbivalent vaccine elicits robust adaptive immune responses against lethal challenge in marbled sleepy goby. Fish and Shellfish Immunology 98 (2020) 429–437
16.Qiang Lin, Jie Li, Xiaozhe Fu, Lihui Liu, Hongru Liang, Yinjie Niu, Chuni Huang,Zhibin Huang, Zhaolan Mo, Ningqiu Li*. Hemorrhagic gill disease of Chinese perch caused byAeromonas salmonicida subsp.salmonicidain China. Aquaculture 519 (2020) 734775
17.Qiang Lin, Xiaozhe Fu, Lihui Liu, Hongru Liang, Yinjie Niu, Yuanya Wen,,Zhibin Huang, Ningqiu Li*. Development and application of a sensitive droplet digital PCR (ddPCR) for the detection of infectious spleen and kidney necrosis virus .Aquaculture，2020，529：735697
